Role of noise in gene expression

Day, Date & Time: Thursday, 16th February, 2017 at 4:00 P.M.

Venue: SSCU Auditorium

Genetically identical cells or organisms exhibit remarkable diversity in phenotypic variability even when they have 
identical histories of environmental exposures. This phenomenon is particularly due to the non-deterministic fluctuations, 
or noise of biological mechanisms. Recent studies suggest that the noise has multiple sources, including the stochastic 
or inherently random nature of biochemical reactions of gene expression. In this talk, I will discuss about the role 
of noise in co-ordination of gene expression in a transcriptional network. Change in frequency of input signals 
owing to the calcium concentration can explain the observed co-ordination of gene expression. I will further briefly 
talk about the control of noise in gene expression.

1. Jonathan M. Raser, and Erin K. O'Shea Science 309:2010-2013 (2005)
2. MB Elowit z  AJ Levine  ED Siggia  and PS Swain  Science 297, 1183 (2002)
3. A Eldar and MB Elowit Nature 467, 167-173 (2010)
4. L Cai et al. Nature 455, 485-490 (2008)