Student Seminar
Name: Mr. Sounak Ghosh
Title- Metallosupramolecular Architectures: An Advent TowardsBiomedical and Catalytic Applications
Date & Time: Thursday, 18th January 2024 at 4.00 p.m.
Venue: Rajarshi Bhattacharya Memorial Lecture Hall, Chemical Sciences Building
Abstract:
The curiosity to understand the wonders of nature ledto the birth of new areas in science,one of which is Supramolecular Chemistry. The synthesis of large macromolecules using conventional covalent bonds involves multistep reactions andis thus time-consuming and challenging. Therefore, metallosupramolecular architectures have acted as an alternative and efficient synthetic method for synthesizing targeted macrocyclic structures for the last few decades.Developing sensing platforms to detect target analytes in the biological milieu[1]enhancedthe workflow in disease diagnostics, drug discovery,[2] and the food industry.[3] Not only that, cancer is one of the leading causes of death worldwide. Sophisticated drugs or nanoformulationsthat can kill cancer cells and be biocompatible to normal tissues are most urgently requiredfor cancer patients. As metallosupramolecular architecturesare primarily employed in biological molecules,[4] such as proteins and lipids, through non-covalent interactions, they provide the opportunity to combine with biomolecules, which can act as sensors/detectors, drug delivery systems, and anti-cancer agents.[5] Also, due to the presence of their cavity, these metallosupramolecular architectures enable enhanced selective catalytic reactions, which are important for synthesizing various life-saving drugs.[6]
In this seminar, I shall discuss the various biological applications and catalytic activity of metallosupramolecular architectures, which can detect the exceeding levels of various amino acids or proteins and treatmultiple diseases.
References:
[1] T. Leelasree, M. Dixit, H. Aggarwal, Chemistry of Materials 2023, 35, 416-423.
[2] G. T. Williams, C. J. E. Haynes, M. Fares, C. Caltagirone, J. R. Hiscock, P. A. Gale, Chemical Society Reviews 2021, 50, 2737-2763.
[3] A. P. F. Turner, Chemical Society Reviews 2013, 42, 3184-3196.
[4] D. A. Uhlenheuer, K. Petkau, L. Brunsveld, Chemical Society Reviews 2010, 39, 2817-2826.
[5] X. Li, X. Zhao, W. Wang, Z. Shi, Y. Zhang, Q. Tian, Y. Yao, C. He, C. Duan, Coordination Chemistry Reviews 2023, 495, 215366.
[6] W.-X. Gao, H.-N. Zhang, G.-X. Jin, Coordination Chemistry Reviews 2019, 386, 69-84.