Student Seminar
Name: Mr. Manoj Kumar Sharma
Title: ‘Thermo-responsive Polymers in Biomedical applications’
Date & Time: Wednesday, 13th November 2024 at 4.00 p.m.
Venue: Rajarshi Bhattacharya Memorial Lecture Hall, Chemical Sciences Building
Abstract:
Thermo-responsive polymers represent a compelling class of smart materials that undergo reversible changes in physical properties in response to temperature shifts[1]. This unique characteristic has unlocked diverse applications in biomedicine, particularly in fields like drug delivery, tissue engineering, and cell culture [2]. By leveraging polymers with well-defined lower critical solution temperatures (LCST), it is possible to design systems that respond to physiological or externally applied temperature changes, enabling precise control over drug release[3], scaffold formation, and cell adhesion/detachment processes.
In the seminar, I will explore the key design requirements for thermoresponsive polymers in biomedical contexts, such as biocompatibility, and degradability. Further, the presentation will delve into the functionalization strategies and polymer architectures that enable controlled and reversible gelation behaviour[4], facilitating applications.[5]
References:
1. Yuan, Y.; Raheja, K.; Milbrandt, N. B.; Beilharz, S.; Tene, S.; Oshabaheebwa, S.; Gurkan, U. A.; Samia, A. C. S.; & Karayilan, M. RSC Applied Polymers, 2023 1(2), 158–189.
2. Zhao, C.; Ma, Z.; & Zhu, X. X. Progress in Polymer Science, 2019, 90, 269–291.
3. Balachandra, A.; Chan, E. C.; Paul, J. P.; Ng, S.; Chrysostomou, V.; Ngo, S.; Mayadunne, R.; & van Wijngaarden, P. Drug Delivery, 2019, 26(1), 343–353
4. Xu, Y.; Xu, Y.; Bi, B.; Hou, M.; Yao, L.; Du, Q.; He, A.; Liu, Y.; Miao, C.; Liang, X.; Jiang, X.; Zhou, G.; & Cao, Y. Acta Biomaterialia, 2010, 108, 87–96.
5. Aliakbar Ahovan, Z.; Khosravimelal, S.; Eftekhari, B. S.; Mehrabi, S.; Hashemi, A.; Eftekhari, S.; Brouki Milan, P.; Mobaraki, M.; Seifalian, A. M., & Gholipourmalekabadi, M. International Journal of Biological Macromolecules, 2020, 164, 4475–4486.